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Atrial Septal Defect

Atrial Septal Defect

What conditions are associated with atrial septal defects?

Some babies born with an atrial septal defect also have other heart defects or genetic disorders. Some associated heart defects include:

 

Mitral valve disease.

Pulmonary stenosis.

Ventricular septal defect (VSD).

Associated genetic disorders include:

 

Holt-Oram syndrome.

Down syndrome.

Thrombocytopenia-absent radii (TAR) syndrome.

What is the difference between an atrial septal defect and a patent foramen ovale?

An atrial septal defect (ASD) and a patent foramen ovale (PFO) are both openings in the atrial septum. But ASD is a congenital heart defect, meaning it’s a problem that occurred while a fetus was still in the uterus. Septal tissue should’ve formed in that part of the atrial septum, but didn’t. So a baby is born with a hole in their heart.

 

A patent foramen ovale isn’t a congenital heart defect. Tissue isn’t missing from the atrial septum. Instead, a PFO happens when a normal flap-like opening in a baby’s heart (foramen ovale) doesn’t seal shut after birth. The foramen ovale is normal, and we all have one when we’re born. This is a normal pathway to allow oxygen-rich blood from the placenta to circulate to the fetus’ brain while in the uterus.

 

When we’re born, we no longer need the foramen ovale since our lungs start working. So it usually closes on its own soon after birth and completely seals off in a couple of days or weeks after. When it doesn’t close on its own, it’s called a patent foramen ovale. “Patent” means open or failing to close.

 

A PFO is usually smaller than an ASD. That’s why it doesn’t usually cause any problems or symptoms. The risk of symptoms and problems goes up when an opening in the septum is bigger.

 

PFOs are much more common than ASDs. Estimates show that about 1 in 4 adults have a PFO. Most people never know they have this small opening in their hearts. It’s usually harmless, but people who have a PFO along with heart problems such as atrial fibrillation may face a higher risk of a stroke.

 

How does an atrial septal defect affect a person’s body?

A small ASD doesn’t affect your body much. But larger ASDs can strain the right side of your heart. That’s because the right side of your heart now has extra blood it must pump out to your lungs. Plus, this extra blood flow can slowly damage the blood vessels in your lungs.

 

Problems with large ASD include:

 

Right heart enlargement, which can lead to heart failure if left uncorrected for a very long period of time.

Abnormal heart rhythm (arrhythmia), including atrial fibrillation or atrial flutter. At least half of adults over age 40 with an ASD have an arrhythmia.

Stroke.

Pulmonary hypertension. This is high blood pressure in the arteries that supply blood to your lungs.

Eisenmenger syndrome. This condition can happen in people who have an ASD along with severe pulmonary hypertension.


What are the symptoms of an atrial septal defect?

Even though an atrial septal defect is present at birth, many people don’t have symptoms until far into adulthood. Small ASDs (less than 5 millimeters) may not cause symptoms because they don’t strain the heart or lungs.

 

Symptoms of an ASD in children

Most children have no signs or symptoms. The most common (and often the only) sign will be a heart murmur. Their healthcare provider will notice it when listening to their heart with a stethoscope.

 

When children do have other symptoms, they include:

 

Being underweight.

Growth delays.

Recurrent respiratory infections.

Although extremely rare, children with larger ASDs may have symptoms that include:

 

Arrhythmias.

Easily becoming fatigued when exercising.

Trouble breathing.

Tell your child’s provider about any symptoms you notice. Their provider may want to run some tests to check your child’s heart structure and function.

 

Symptoms of an ASD in adults

Adults with ASD may feel symptoms by age 40. Symptoms depend on how much the ASD has strained the heart and lungs. They include:

 

Fatigue.

Shortness of breath with exercise.

Heart palpitations.

Fast heartbeat (tachycardia).

Swelling in the arms and legs.

Blue skin color (cyanosis).

If you have any of these symptoms, call your healthcare provider right away. These symptoms could mean you have an untreated ASD. Or, they could mean you have another cardiovascular problem that needs treatment. If you have chest pain, you should call 911 or your local emergency number.

 

What causes atrial septal defects?

The exact cause of atrial septal defects isn’t fully known. However, congenital heart defects are often caused by genetic changes that happen before birth. Some genetic mutations associated with ASD affect the NKX2.5/CSX and TBX5 genes.

 

Some factors can raise a birthing parent’s risk of having a baby with congenital heart disease. These factors include:

 

Alcohol consumption.

Smoking and tobacco use.

Taking certain prescription medications.


How are atrial septal defects diagnosed?

Atrial septal defects are diagnosed through a physical exam along with tests that check your heart’s structure and function.

 

Tests to diagnose atrial septal defects

Your provider will run one or more tests to diagnose you with an ASD and learn how it’s affecting your heart. These include:

 

Electrocardiography (ECG/EKG). An ECG shows your heart’s electrical activity. It can reveal if you have an arrhythmia or other problems related to your heart’s electrical system.

Chest X-ray. This test will show if your right atrium and right ventricle are enlarged. It’ll also show if the blood vessels in your lungs are affected.

Transthoracic echocardiography (TTE). This test shows how the left-to-right shunting of blood (caused by ASD) affects your heart. It can also show details related to pulmonary hypertension.

Transesophageal echocardiography (TEE). A TEE is an ultrasound taken through your esophagus. It shows the size, shape and location of an ASD. It can also check your heart valves. TEE is often used during ASD surgery and percutaneous repair.

Intracardiac echocardiography (ICE). This is an ultrasound taken inside your heart. A tiny camera (echo probe) is sent to your heart through a peripheral vein. This test shows the size and shape of the ASD and the direction of the blood flow across it. It’s often used during percutaneous (nonsurgical) repair of ASD.

In some cases, Cardiac CT scan or Heart MRI may be used. They’re most helpful for people with associated defects or less common forms of ASD.


What is the treatment for an atrial septal defect?

Atrial septal defects can be closed through surgery or percutaneous (nonsurgical) repair.

 

The type and timing of ASD treatment depends on many factors, including:

 

ASD type and size.

How the ASD is affecting your heart.

Other conditions you have, like pulmonary hypertension, valve disease or coronary artery disease.

Small ASDs usually don’t need repair. However, larger ASDs should be repaired even if they aren’t causing symptoms. This prevents serious complications down the road.

 

Once you have signs of heart or lung damage, repair is essential. Your provider will recommend treatment if:

 

The right side of your heart is bigger than normal.

There’s significant shunting (flow of blood through the ASD).

Your provider may prescribe medications to treat some symptoms of ASD. But there aren’t any medications that can close the hole.

 

If you have pulmonary hypertension, you may need to take medication before your repair procedure. This medication treats pulmonary hypertension and makes the procedure safer for you.

 

Percutaneous (nonsurgical) repair of ASDs

This type of repair uses a device (called a septal occluder) to close the hole in your atrial septum. The device is put in place using a long, thin tube called a catheter. The occluder is attached to the catheter, which is guided to your heart through a vein in your groin. When the occluder is released from the catheter, it opens up and seals the hole. Over time, tissue grows over the occluder, and it becomes part of your heart.

 

Percutaneous repair can close most secundum ASDs and some sinus venosus ASDs. So, this is the method used most often.

 

Before the repair, you’ll have a cardiac catheterization to check the size and location of the ASD and measure pressures in your heart.

 

After the repair, you’ll take blood-thinning medication (anticoagulant or antiplatelet) to keep blood clots from forming on the device (a possible but rare complication). Your provider will talk with you about the right type of medication for you and how long you need to take it.

 

Surgical repair of ASDs

Surgery is needed for primary ASDs, coronary sinus defects and most sinus venosus ASDs. These are rare defects that require treatment by a cardiac surgeon with expertise in congenital heart disease. Robotic-assisted surgery or minimally invasive surgery may be options for some people.

 

A surgical repair usually involves using a tissue patch to close the ASD. The tissue often comes from your own pericardium (the membrane around your heart). Some secundum ASDs can be surgically closed with just sutures and no patch.

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